Product Description
PE-22-28 is a synthetic heptapeptide analog derived from spadin, a naturally occurring peptide fragment of the sortilin protein. This shortened seven-amino-acid sequence represents the most active region of spadin and acts as a potent TREK-1 (TWIK-related potassium channel) inhibitor with an IC50 value of 0.12 nM.
Research investigations have examined PE-22-28 peptide in studies of two-pore potassium channel activity, serotonergic neuron firing rates, neurogenesis and synaptogenesis pathways, and CREB signaling mechanisms in neurological models. The compound is used in controlled laboratory environments for investigating mood regulation pathways, hippocampal neurogenesis, BDNF expression modulation, and neuroprotective mechanisms in cellular studies.
Supplied as pharmaceutical-grade spray with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Peptide Specifications
| SPECIFICATION | DESCRIPTION |
|---|---|
| Sequence | Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) |
| Molecular Formula | C35H55N11O9 |
| Molecular Weight | 773.89 g/mol |
| CAS Number | 1801959-12-5 |
| Synonyms | PE22-28, PE2228, TREK-1 Inhibitor, Spadin Analog |
| Purity | ≥99% (HPLC) |
| Presentation | Spray |
| Shelf Life | 36 months from date of manufacture when stored properly |
| Quality Verification | Third-party tested by certified laboratory |
| Manufacturing Standard | USA-made, pharmaceutical-grade, GMP compliant |
| Intended Application | In vitro research applications only |
Our Product Quality Guarantee
Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.
Buy PE-22-28 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PE-22-28 for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
