What is MOTS-C?

MOTS-C is a mitochondria-derived peptide consisting of 16 amino acids. Its name refers to a mitochondrial open reading frame within the 12S rRNA region.

MOTS-C has been investigated in cell-based and mouse studies of mitochondrial signaling and cellular metabolism. A 2015 study examined its relationship with the folate-purine pathway and AMPK, an enzyme involved in cellular energy sensing. These findings describe experimental models, not expected outcomes from a Limitless Biotech product.

Available material and documentation

The MOTS-C peptide for sale from Limitless Biotech is identified by the sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, molecular formula C101H152N28O22S2, and molecular weight 2,174.6 g/mol. Review the selected weight and grade alongside the applicable product specifications.

Premium Lyophilized material is manufactured in the United States and has a minimum purity specification of at least 99%. Its testing program includes independent purity and quantitative testing, plus sterility and endotoxin testing.

Standard Non-Lyophilized material has a minimum purity specification of at least 98.5%; the raw material is manufactured overseas, with Limitless Biotech handling vialing, internal quality control, and independent purity testing.

This product may contain trehalose as a lyoprotectant/solubility agent. Match storage instructions to the selected material and its current condition. Instructions for unopened lyophilized material do not establish the storage conditions or lifetime of material in solution.

The Limitless Biotech MOTS-C peptide is only available for in vitro research studies. It is not appropriate for human or animal use. 

Available Certificates of Analysis (COAs) provide analytical results for the tested material. Match the compound, material grade, labeled amount, and batch to the report. Chromatographic purity does not establish the amount of MOTS-C in the sample; quantitative testing addresses that separate question where included.

Research context

A 2018 study in cultured cells investigated AMPK-dependent movement of MOTS-C into the nucleus during metabolic stress and associated changes in gene expression. This provides a defined context for cellular research rather than evidence of personal metabolic or longevity outcomes.

Explore Mitochondrial Research for related research materials, or browse our research peptides to compare individual compounds.

For broader handling considerations, review our peptide storage and handling guide alongside the material-specific instructions. View MOTS-C specifications and log in for professional pricing.

Frequently asked questions

What is MOTS-C?

MOTS-C is a mitochondria-derived peptide consisting of 16 amino acids. Its name refers to a mitochondrial open reading frame within the 12S rRNA region. Limitless Biotech supplies it for laboratory research only, not for human or animal use.

How do the available grades differ?

Premium Lyophilized and Standard Non-Lyophilized materials differ in processing, sourcing, minimum purity specification, and testing scope. Premium material has a minimum specification of at least 99%; Standard material has a minimum specification of at least 98.5%. Review the applicable product documentation for storage requirements rather than inferring shelf life from the grade name.

What information should be checked in the applicable COA?

Check the compound identity, material grade, labeled amount, batch, report date, analytical methods, and results. Confirm which purity, identity, quantitative, sterility, and endotoxin results apply rather than assuming every report contains the same panel.