Livagen Peptide Description
Livagen is a tetrapeptide bioregulator composed of the amino acid sequence Lys-Glu-Asp-Ala. This laboratory-grade peptide demonstrates remarkable biological activity in experimental settings, particularly in hepatocyte culture studies.
Research shows that nanomolar concentrations of Livagen significantly enhance protein synthesis rates in aged hepatocyte cultures, restoring functionality comparable to young specimens. A notable property of this peptide is its ability to restore disrupted intracellular circadian rhythms of biosynthesis.
Livagen's mechanism of action involves the endogenous opioid system, where it effectively inhibits enkephalin-degrading enzymes with superior efficiency compared to conventional peptidase inhibitors. Interestingly, the peptide does not directly interact with opioid receptors, suggesting its biological effects occur through alternative pathways.
This unique bioregulator influences chromatin structure through selective heterochromatin modifications, enabling the activation of previously silenced genes in cellular models. Livagen represents a valuable research tool for laboratories investigating cellular rejuvenation mechanisms and protein synthesis pathways.
Peptide Specifications
- Sequence: H-Lys-Glu-Asp-Ala-OH
- Molecular Formula: C18H31N5O9
- Molecular Weight: 461.5 g/mol
- PubChem CID: 51351754
- Synonyms: L-Ala-gamma-D-Glu-meso-DAP-D-Ala, L-Ala-gamma-D-Glu-DAP-D-Ala, CHEBI:62015, Q27131529, L-alanyl-N-[(2R,6S)-6-amino-6-carboxy-1-{[(1R)-1-carboxyethyl]amino}-1-oxohexan-2-yl]-D-glutamine
- Storage: For optimal preservation in laboratory settings, Livagen should be stored in lyophilized form at -20°C or below, while peptide solutions require refrigeration at 4°C
Research Applications
- Chromatin Modification
- Genomic Stability
- Cardiovascular Conditions
- Opioid System Interaction
- Digestive Enzyme Activity
- Short Description:
- Livagen is a synthetic tetrapeptide composed of the amino acids lysine, glutamic acid, aspartic acid, and alanine. This peptide is formulated to serve as an exemplary model substrate in studies of protease specificity and kinetics, particularly for e
- Container:
- Glass Vial
- Presentation:
- Liquid
