Product Description
PNC-27 is a synthetic 32-amino-acid chimeric peptide containing an HDM-2 binding domain derived from p53 tumor suppressor protein (residues 12-26) fused to a cell-penetrating peptide (CPP) sequence from antennapedia. This membrane-active peptide binds selectively to HDM-2 proteins expressed on cancer cell membranes, inducing transmembrane pore formation through membranolysis mechanisms.
Research investigations have examined PNC-27 in studies of HDM-2/p53 protein interactions, selective membrane disruption pathways, cancer cell necrosis mechanisms, and oligomeric pore formation in cellular membranes. The compound is used in controlled laboratory environments for investigating anticancer peptide mechanisms, membrane permeabilization processes, and selective cytotoxicity pathways in various cancer cell lines including breast, pancreatic, ovarian, leukemia, and melanoma models.
Supplied as pharmaceutical-grade lyophilized powder with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Peptide Specifications
| SPECIFICATION | DESCRIPTION |
|---|---|
| Sequence | Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly (32 amino acids) |
| Molecular Formula | C188H293N53O44S |
| Molecular Weight | 4031.7 g/mol |
| CAS Number | 1159861-00-3 |
| Synonyms | PNC27, PNC 27, Chimeric p53-penetratin peptide |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in sterile water (≥100 μg/mL), can be further diluted in aqueous solutions |
| Storage Conditions | Store lyophilized at -18°C; reconstituted: 4°C for 2-7 days, -18°C for long-term storage; add carrier protein (0.1% HSA/BSA) for extended storage |
| Physical Appearance | White lyophilized powder |
| Shelf Life | Stable at room temperature for 3 weeks desiccated; 36 months at -18°C |
| Quality Verification | Third-party tested by certified laboratory |
| Manufacturing Standard | USA-made, pharmaceutical-grade, GMP compliant |
| Intended Application | In vitro research applications only |
Our Product Quality Guarantee
Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.
Buy PNC-27 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PNC-27 anti-cancer peptide for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
