Product Description
PNC-28 is a synthetic 27-amino-acid chimeric peptide containing a shorter HDM-2 binding domain derived from p53 tumor suppressor protein (residues 17-26) fused to the same cell-penetrating peptide (CPP) sequence used in PNC-27. This membrane-active peptide represents a truncated analog that lacks the first five amino acids of PNC-27's p53 domain while retaining selective cytotoxic activity against cancer cells.
Research investigations have examined PNC-28 in studies of HDM-2/p53 protein interactions, pancreatic cancer cell necrosis mechanisms, transmembrane pore formation, and penetratin-mediated cell entry pathways. The compound is used in controlled laboratory environments for investigating anticancer peptide structure-activity relationships, membrane disruption mechanisms, and selective tumor cell targeting in various cancer cell lines including pancreatic, ovarian, and breast cancer models.
Supplied as pharmaceutical-grade lyophilized powder with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Peptide Specifications
| SPECIFICATION | DESCRIPTION |
|---|---|
| Sequence | Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly (27 amino acids) |
| p53 Domain | ETFSDLWKLL (residues 17-26) |
| Penetratin Domain | KKWKMRRNQFWVKVQRG (membrane-crossing sequence) |
| Cyclic Form (p53 only) | C64H88N12O16 (MW: 1233.64 g/mol) |
| CAS Number | 392661-17-5 |
| Synonyms | PNC28, PNC 28, p53 17-26 penetratin peptide |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in sterile water, can be further diluted in aqueous solutions |
| Storage Conditions | Store lyophilized at -20°C; reconstituted: 4°C for 2-7 days, -20°C for long-term storage |
| Physical Appearance | White lyophilized powder |
| Shelf Life | 36 months from date of manufacture when stored properly |
| Quality Verification | Third-party tested by certified laboratory |
| Manufacturing Standard | USA-made, pharmaceutical-grade, GMP compliant |
| Intended Application | In vitro research applications only |
Our Product Quality Guarantee
Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.
Buy PNC-28 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PNC-28 anti-cancer peptide for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
